TransCon refers to “transient conjugation”, or our unique ability to temporarily (transiently) link an inert carrier to a parent drug with known biology.
Depending on the carrier used, TransCon prodrugs can be designed to act systemically (throughout the body) or locally (e.g. intratumorally), focused on meeting a specific therapeutic goal. TransCon is widely applicable to proteins, peptides or small molecules in multiple therapeutic areas.

TransCon molecules have three components: an unmodified parent drug with known biology, an inert carrier that protects it, and a linker that temporarily binds the two. When bound, the carrier inactivates and shields the parent drug from clearance. When injected, physiologic conditions in the body initiate the release of the active, unmodified parent drug in a predictable manner at a predetermined rate. Because the parent drug is unmodified, its original mode of action is expected to be maintained.